In our study (1) we observed a reduced incidence of atrial fibrillation (AF) following coronary artery bypass surgery in patients receiving polyunsaturated fatty acids (PUFAs). The way these compounds could have determined this result is, at present, only speculative. Indeed, PUFAs have been demonstrated to have a direct anti-arrhythmic effect in different laboratory models, but the importance of a concurrent (or prevalent) anti-inflammatory action cannot be excluded. In fact, PUFAs have anti-inflammatory properties (2), and inflammation, as correctly pointed out by Dr. Korantzopoulos and colleagues can play a fundamental role in postcardiac surgery AF. Actually, the efficacy of an anti-inflammatory therapy in this setting is still not clear owing to conflicting reports. Whereas a single postinduction steroid administration was shown to prevent postoperative AF (3), a similar protocol was found ineffective in other hands (4). The debate on this subject is thus still open, but unfortunately a further contribution cannot be obtained by our study, because C-reactive protein (CRP) levels or other inflammatory indexes were not routinely collected in our patients.