A custom blend of altruism and self-interest motivates each individual, institution, and company involved in every phase of health care, whether it’s inventing drugs, conducting trials, developing guidelines, educating doctors, or performing procedures. As medical professionals, we must assure patients and the public that altruism is our primary motivating force. And because academics influence so many important parts of the trial-guideline-education process, they have a special responsibility to ensure its integrity. Academics help design and carry out clinical trials. They also publish papers, write editorials, give talks, and create guidelines that influence practice. These are valuable activities, and the significant time and energy academics devote to them must be acknowledged—and compensated.