In the year 2001, 64% of submissions originated from outside the U.S., a 2% increase over the foreign submission rate of 2000. Japan leads the foreign submissions, followed by Germany, Italy, the United Kingdom, Canada, the Netherlands and France. The impact factor has risen to 7.082. We maintained the strong clinical content of the Journal with 87% clinical articles and 13% experimental studies. Subscriptions for December 2001 totaled 32,833. Since January 1, 2002, all new manuscripts have been directed to the new Editor-in-Chief, Dr. Anthony DeMaria in San Diego, and the official changeover date is July 1, 2002.