Previous investigations excluded patients with impaired renal function (GFR <45 ml/min/1.73 m2) or progressive chronic kidney disease, because no data were available regarding potential RSD-related functional or structural kidney damage, or both ((1),(2),3). We conducted serial measurements of urinary NGAL and KIM-1 concentrations after RSD, in addition to sCr and eGFR measurements, to look for procedure-related functional and structural kidney damage after RSD, also considering patients with impaired renal function (eGFR <45 ml/min/1.73 m2). Our results demonstrate that urinary NGAL and KIM-1 concentrations did not increased during the following 2 days after RSD or after 3 months follow-up. The same holds true when patients with a eGFR <45 ml/min/1.73 m2 were investigated. In accordance with this observation, we additionally did not observe alteration in sCR, blood urea nitrogen, or eGFR measurements.