CLINICAL STUDY: RISK FACTORS
Alcohol consumption and risk of coronary heart disease among men with type 2 diabetes mellitus
Mihaela Tanasescu, MD*,*,
Frank B. Hu, MD*,
Walter C. Willett, MD*   ,
Meir J. Stampfer, MD* and
Eric B. Rimm, ScD*
* Nutrition, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Epidemiology, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Harvard School of Public Health, the Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Manuscript received March 27, 2001;
revised manuscript received August 22, 2001,
accepted August 31, 2001.
* Reprint requests and correspondence: Dr. Mihaela Tanasescu, Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115 USA
mtanases{at}hsph.harvard.edu
OBJECTIVES
The goal of this study was to examine the relationship between alcohol intake and risk of coronary heart disease (CHD) among men with type 2 diabetes.
BACKGROUND
Type 2 diabetes is associated with an increased risk of CHD. Emerging evidence suggests that moderate alcohol intake is associated with an important reduction in risk of CHD in individuals with type 2 diabetes.
METHODS
We studied 2,419 men who reported a diagnosis of diabetes at age 30 or older in the Health Professionals’ Follow-up study (HPFS). During 11,411 person-years of follow-up after diagnosis, we documented 150 new cases of CHD (81 nonfatal myocardial infarction [MI] and 69 fatal CHD). Relative risks (RR) were estimated from pooled logistic regression adjusting for potential confounders.
RESULTS
Alcohol use was inversely associated with risk of CHD in men with type 2 diabetes. The age-adjusted RRs corresponding to intakes of  0.5 drinks/day, 0.5 to 2 drinks/day and >2 drinks/day were 0.76 (95% confidence interval: [CI]: 0.52 to 1.12), 0.64 (95% CI: 0.40 to 1.02) and 0.59 (95% CI: 0.32 to 1.09), respectively, as compared with nondrinkers (p for trend = 0.06). When we controlled for body mass index, smoking, family history of MI, hypertension, hypercholesterolemia, duration of diabetes, physical activity level, vitamin E supplements and intake of trans fat, polyunsaturated fat, fiber and folate, RRs were 0.78 (95% CI: 0.52 to 1.15), 0.62 (95% CI: 0.40 to 1.00) and 0.48 (95% CI: 0.25 to 0.94) (p for trend = 0.03). The benefits of moderate consumption did not statistically differ by beverage type.
CONCLUSIONS
Moderate alcohol consumption is associated with lower risk of CHD in men with type 2 diabetes.
|
Abbreviations and Acronyms
| | AGE | = advanced glycation end products | | BMI | = body mass index | | CHD | = coronary heart disease | | CI | = confidence interval | | HDL-C | = high-density lipoprotein cholesterol | | HPFS | = Health Professionals’ Follow-up study | | MI | = myocardial infarction | | PAI-1 | = plasminogen activator inhibitor 1 | | RR | = relative risk | | t-PA | = tissue type plasminogen activator |
|
This article has been cited by other articles:
|
|
|
|
 
I. Wakabayashi
Comparison of the Relationships of Alcohol Intake with Atherosclerotic Risk Factors in Men with and without Diabetes Mellitus
Alcohol Alcohol.,
May 1, 2011;
46(3):
301 - 307.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. Halanych, M. M. Safford, S. G. Kertesz, M. J. Pletcher, Y.-I. Kim, S. D. Person, C. E. Lewis, and C. I. Kiefe
Alcohol Consumption in Young Adults and Incident Hypertension: 20-Year Follow-up From the Coronary Artery Risk Development in Young Adults Study
Am. J. Epidemiol.,
March 1, 2010;
171(5):
532 - 539.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Kerr, S. Penfold, S. Zouwail, P. Thomas, and J. Begley
The influence of liberal alcohol consumption on glucose metabolism in patients with type 1 diabetes: a pilot study
QJM,
March 1, 2009;
102(3):
169 - 174.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. O'Keefe, K. A. Bybee, and C. J. Lavie
Alcohol and Cardiovascular Health: The Razor-Sharp Double-Edged Sword
J. Am. Coll. Cardiol.,
September 11, 2007;
50(11):
1009 - 1014.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. W.J. Beulens, E. B. Rimm, A. Ascherio, D. Spiegelman, H. F.J. Hendriks, and K. J. Mukamal
Alcohol Consumption and Risk for Coronary Heart Disease among Men with Hypertension
Ann Intern Med,
January 2, 2007;
146(1):
10 - 19.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. J. Mukamal, S. E. Chiuve, and E. B. Rimm
Alcohol consumption and risk for coronary heart disease in men with healthy lifestyles.
Arch Intern Med,
October 23, 2006;
166(19):
2145 - 2150.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. J. Mukamal, A. Ascherio, M. A. Mittleman, K. M. Conigrave, C. A. Camargo Jr, I. Kawachi, M. J. Stampfer, W. C. Willett, and E. B. Rimm
Alcohol and Risk for Ischemic Stroke in Men: The Role of Drinking Patterns and Usual Beverage
Ann Intern Med,
January 4, 2005;
142(1):
11 - 19.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Avogaro, R. M. Watanabe, A. Dall'Arche, S. Vigili De Kreutzenberg, A. Tiengo, and G. Pacini
Acute Alcohol Consumption Improves Insulin Action Without Affecting Insulin Secretion in Type 2 Diabetic Subjects
Diabetes Care,
June 1, 2004;
27(6):
1369 - 1374.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. A. Howard, J. H. Arnsten, and M. N. Gourevitch
Effect of Alcohol Consumption on Diabetes Mellitus: A Systematic Review
Ann Intern Med,
February 3, 2004;
140(3):
211 - 219.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. R. Zilkens, V. Burke, G. Watts, L. J. Beilin, and I. B. Puddey
The Effect of Alcohol Intake on Insulin Sensitivity in Men: A randomized controlled trial
Diabetes Care,
March 1, 2003;
26(3):
608 - 612.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. McCulloch, R. McDermott, G. Miller, D. Leonard, M. Elwell, and R. Muller
Self-Reported Diabetes and Health Behaviors in Remote Indigenous Communities in Northern Queensland, Australia
Diabetes Care,
February 1, 2003;
26(2):
397 - 403.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. D. Mooradian
Cardiovascular Disease in Type 2 Diabetes Mellitus: Current Management Guidelines
Arch Intern Med,
January 13, 2003;
163(1):
33 - 40.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Liu, Z. Tian, B. Gao, and G. Kunos
Dose-dependent Activation of Antiapoptotic and Proapoptotic Pathways by Ethanol Treatment in Human Vascular Endothelial Cells. DIFFERENTIAL INVOLVEMENT OF ADENOSINE
J. Biol. Chem.,
May 31, 2002;
277(23):
20927 - 20933.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
